Resumen (en inglés): Victorian literature is rife with scenes of madness, with mental disorder functioning as everything from a simple plot device to a commentary on the foundations of Victorian society. But while madness in Victorian fiction has been much studied, most scholarship has focused on the portrayal of madness in women; male mental disorder in the period has suffered comparative neglect. In ‘The Most Dreadful Visitation’, Valerie Pedlar redresses the balance. This extraordinary study explores a wide range of Victorian writings to consider the relationship between the portrayal of mental illness in literary works and the portrayal of similar disorders in the writings of doctors and psychologists. Pedlar presents in-depth studies of Dickens’s Barnaby Rudge, Tennyson’s Maud, Wilkie Collins’s Basil and Trollope’s He Knew He Was Right, considering each work in the context of Victorian understandings – and fears – of mental degeneracy.
Alzheimer's Disease: Lifecourse Perspectives on Risk Reduction summarizes the growing body of knowledge on the distribution and causes of Alzheimer’s disease (AD) in human populations, providing the reader with knowledge on how we define the disease and what its risk and protective factors are in the context of a life-course approach.
At the conclusion of the book, the reader will understand why Alzheimer’s disease likely begins at conception, then progresses through early-life and adult risk factors that ultimately impact the balance between pathologic insults in the brain and the ability of the brain to modify disease symptoms. In contrast to edited volumes that may have little cohesion, this book focuses on an integrated life-course approach to the epidemiology of dementia, in particular, Alzheimer’s disease.
Reviews the current science surrounding Alzheimer’s disease
Provides a primer of foundational knowledge on the disease's epidemiology and biostatistics
Utilizes a life-course approach, providing a novel and integrated view of the evolution of this illness from genes to brain reserve
Uses the ‘threshold model’—a theory first described by Dr. Mortimer and widely accepted today—which incorporates the idea of risk factors for the pathology and expression of the disease
Proposes that improving brain health through modifiable behaviors can delay disease onset until a later age
Examines the future of prevention of Alzheimer’s disease, a subject of great current interest
A Neuronal Mechanism in the Generation of Thought–A New Molecular Model
Academic Press, 2015.
Resumen (en inglés):
The question of "what is thought" has intrigued society for ages, yet it is still a puzzle how the human brain can produce a myriad of thoughts and can store seemingly endless memories. All we know is that sensations received from the outside world imprint some sort of molecular signatures in neurons – or perhaps synapses – for future retrieval. What are these molecular signatures, and how are they made? How are thoughts generated and stored in neurons? The Biology of Thought explores these issues and proposes a new molecular model that sheds light on the basis of human thought. Step-by-step it describes a new hypothesis for how thought is produced at the micro-level in the brain – right at the neuron.
Despite its many advances, the neurobiology field lacks a comprehensive explanation of the fundamental aspects of thought generation at the neuron level, and its relation to intelligence and memory. Derived from existing research in the field, this book attempts to lay biological foundations for this phenomenon through a novel mechanism termed the "Molecular-Grid Model" that may explain how biological electrochemical events occurring at the neuron interact to generate thoughts. The proposed molecular model is a testable hypothesis that hopes to change the way we understand critical brain function, and provides a starting point for major advances in this field that will be of interest to neuroscientists the world over.
Written to provide a comprehensive coverage of the electro-chemical events that occur at the neuron and how they interact to generate thought
Provides physiology-based chapters (functional anatomy, neuron physiology, memory) and the molecular mechanisms that may shape thought
Contains a thorough description of the process by which neurons convert external stimuli to primary thoughts