Microbial Proteins and Host Cell Dysregulation Vol. Special Issue
Krakauer, Teresa (ed.)
MDPI AG - Multidisciplinary Digital Publishing Institute, 2016.
Título de la serie/colección:Toxins. ISSN 2072-6651,
Colección: Directory of Open Access Books
Resumen (en inglés): Enterotoxins encompass a diverse group of microbial toxins affecting the gut and are major contributors to bacterial food borne illness, gastrointestinal and systemic diseases for which limited therapeutics are available. Although the pathogenic effects arise from mucosal perturbation, dysregulation of immune cells through mediator release, cell activation or damage are major factors disrupting homeostasis in gut mucosa. Whereas proinflammatory cytokines and chemokines mediate toxic shock induced by staphylococcal enterotoxins, apoptosis and cytotoxic events are responsible for Clostridium perfringens enterotoxin and cholera toxin. Understanding of receptors, signaling pathways and the communication between cells of the gastrointestinal tract, immune and neuroendocrine system will facilitate the development of new therapeutics.