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Gran Área: Ciencias médicas y de la salud
Área: Medicina básica
Subárea: Inmunología

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Resultado: 149 registro(s)

16866

Autophagy

Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging Vol. 3

 

Academic Press, 2014.

ISBNs 9780124055292

Colección: ScienceDirect

Resumen (en inglés):

Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and up-to-date, this book offers a valuable guide to these cellular processes whilst encouraging researchers to explore their potentially important connections.

Volume 3 explores the role of autophagy in specific diseases and developments, including: Crohn’s Disease, Gaucher Disease, Huntington’s Disease, HCV infection, osteoarthritis, and liver injury. A full section is devoted to in-depth exploration of autophagy in tumor development and cancer. Finally, the work explores the relationship between autophagy and apoptosis, with attention to the ways in which autophagy regulates apoptosis, and the ways in which autophagy has been explored in Lepidoptera, elucidating the use of larval midgut as a model for such exploration.  From these well-developed foundations, researchers, translational scientists, and practitioners may work to better implement more effective therapies against some of the most devastating human diseases.

Volumes in the Series

Volume 1: Molecular Mechanisms. Elucidates autophagy’s association with numerous biological processes, including cellular development and differentiation, cancer, immunity, infectious diseases, inflammation, maintenance of homeostasis, response to cellular stress, and degenerative diseases such as Alzheimer’s, Parkinson's, Huntington's, amyotrophic lateral sclerosis, and prion diseases. Volume 2: Role in General Diseases. Describes the various aspects of the complex process of autophagy in a myriad of devastating human diseases, expanding from a discussion of essential autophagic functions into the role of autophagy in proteins, pathogens, immunity, and general diseases.  Volume 3: Role in Specific Diseases. Explores the role of autophagy in specific diseases and developments, including: Crohn’s Disease, Gaucher Disease, Huntington’s Disease, HCV infection, osteoarthritis, and liver injury, with a full section devoted to in-depth exploration of autophagy in tumor development and cancer, as well as the relationship between autophagy and apoptosis. Volume 4: Mitophagy. Presents detailed information on the role of mitophagy, the selective autophagy of mitochondria, in health and disease, by delivering an in-depth treatment of the molecular mechanisms involved in mitophagy initiation and execution, as well as the role of mitophagy in Parkinson Disease, cardiac aging, and skeletal muscle atrophy. Volume 5: Role in Human Diseases. Comprehensively describes the role of autophagy in human diseases, delivering coverage of the antitumor and protumor roles of autophagy; the therapeutic inhibition of autophagy in cancer; and the duality of autophagy’s effects in various cardiovascular, metabolic, and neurodegenerative disorders. Volume 6: Regulation of Autophagy and Selective Autophagy. Provides coverage of the mechanisms of regulation of autophagy; intracellular pathogen use of the autophagy mechanism; the role of autophagy in host immunity; and selective autophagy. Volume 7: Role of Autophagy in Therapeutic Applications. Provides coverage of the latest developments in autophagosome biogenesis and regulation; the role of autophagy in protein quality control; the role of autophagy in apoptosis; autophagy in the cardiovascular system; and the relationships between autophagy and lifestyle.  Volume 8: Autophagy and Human Diseases. Reviews recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities, and introduces new, more effective therapeutic strategies, in the development of targeted drugs and programmed cell death, providing information that will aid on preventing detrimental inflammation. Volume 9: Necrosis and Inflammation in Human Diseases. Emphasizes the role of Autophagy in necrosis and inflammation, explaining in detail the molecular mechanism(s) underlying the formation of autophagosomes, including the progression of Omegasomes to autophagosomes.

  • Brings together oncologists, neurosurgeons, physicians, research scientists, and pathologists in the field of autophagy to discuss cutting-edge developments in this rapidly-advancing field
  • Builds upon recent advances in genome-scale approaches and computational tools to discuss the advances in regulation of autophagy at the systems level
  • Organized for readers into easy-to-access sections: molecular mechanisms; role of autophagy in disease; role of autophagy in cancer; and autophagy and apoptosis
  • Explores exciting new developments, including the measurement of autophagic flux; the molecular role of the Atg12-Atg5-Atg16 complex; and the molecular bases of autophagosome formation in yeast


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525

Bacterial Genomes and Infectious Diseases

 

13th ed. Totowa, NJ: Humana Press Inc., 2006.

ISBNs 9781588294968 9781597451529

Colección: SpringerLink


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8973

Basal Ganglia VIII, The

Vol. 56

 

13th ed. Boston, MA: Springer Science+Business Media, 2005.

Título de la serie/colección: Advances in Behavioral Biology.

ISBNs 9780387280653 9780387280660

Colección: SpringerLink


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206

Biogenesis of Cellular Organelles, The

 

13th ed. Boston, MA: Eurekah.com/Kluwer Academic/Plenum Publishers, 2005.

Título de la serie/colección: Molecular Biology Intelligence Unit.

ISBNs 9780306479908 9780387268675

Colección: SpringerLink


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3221

Biologics in General Medicine

 

13th ed. Berlin, Heidelberg: Springer-Verlag, 2007.

ISBNs 9783540290179 9783540290186

Colección: SpringerLink


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6685

Biology of Dendritic Cells and HIV Infection, The

 

13th ed. Boston, MA: Springer Science+Business Media, 2007.

ISBNs 9780387337845 9780387337852

Colección: SpringerLink


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3458

Bone Marrow-Derived Progenitors

Vol. 180

 

13th ed. Berlin, Heidelberg: Springer-Verlag, 2007.

Título de la serie/colección: Handbook of Experimental Pharmacology. ISSN 0171-2004,

ISBNs 9783540689751 9783540689768

Colección: SpringerLink


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17139

Cancer Immunotherapy

Immune Suppression and Tumor Growth

 

2nd ed. Academic Press, 2013.

ISBNs 9780123942968

Colección: ScienceDirect

Resumen (en inglés):

There has been major growth in understanding immune suppression mechanisms and its relationship to cancer progression and therapy. This book highlights emerging new principles of immune suppression that drive cancer, and it offers radically new ideas about how therapy can be improved by attacking these principles. Following work that firmly establishes immune escape as an essential trait of cancer, recent studies have now defined specific mechanisms of tumor immune suppression. It also demonstrates how attacking tumors with molecular targeted therapeutics or traditional chemotherapeutic drugs can produce potent anti-tumor effects in preclinical models. This book provides basic, translational, and clinical cancer researchers with an indispensable overview of immune escape as a critical trait in cancer and how applying specific combinations of immunotherapy and chemotherapy to attack this trait may radically improve the treatment of advanced disease.

  • Offers a synthesis of concepts that are useful to cancer immunologists and pharmacologists, who tend to work in disparate fields with little cross-communication
  • Drs. Prendergast and Jaffee are internationally recognized leaders in cancer biology and immunology who have created a unique synthesis of fundamental and applied concepts in this important new area of cancer research
  • Summarizes the latest insights into how immune escape defines an essential trait of cancer
  • Includes numerous illustrations, including how molecular-targeted therapeutic drugs or traditional chemotherapy can be combined with immunotherapy to improve anti-tumor efficacy and how reversing immune suppression by the tumor can cause tumor regression


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9001

CD137 Pathway

Immunology and Diseases

 

13th ed. Boston, MA: Springer, 2007.

ISBNs 9780387313221 9780387328294

Colección: SpringerLink


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2798

CD4+CD25+ Regulatory T Cells

Origin, Function and Therapeutic Potential Vol. 293

 

13th ed. Berlin, Heidelberg: Springer-Verlag, 2005.

Título de la serie/colección: Current Topics in Microbiology and Immunology. ISSN 0070-217X,

ISBNs 9783540244448 9783540277026

Colección: SpringerLink


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