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Gran Área: Ciencias médicas y de la salud
Área: Medicina básica
Subárea: Farmacología y farmacia

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Resultado: 243 registro(s)

23337

CaMKII in Cardiac Health and Disease

 

Frontiers Media SA, 2014.

Título de la serie/colección: Frontiers Research Topics. ISSN 1664-8714,

ISBNs 9782889192991

Colección: Directory of Open Access Books


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17137

Cancer Drug Design and Discovery

 

2nd ed. Academic Press, 2014.

ISBNs 9780123965219

Colección: ScienceDirect

Resumen (en inglés):

Cancer Drug Design and Discovery, Second Edition is an important reference on the underlying principles for the design and subsequent development of new anticancer small molecule agents. New chapters have been added to this edition on areas of particular interest and therapeutic promise, including cancer genomics and personalized medicine, DNA-targeted agents and more. This book includes several sections on the basic and applied science of cancer drug discovery and features those drugs that are now approved for human use and are in the marketplace, as well as those that are still under development. By highlighting some of the general principles involved in taking molecules through basic science to clinical development, this book offers a complete and authoritative reference on the design and discovery of anticancer drugs for translational scientists and clinicians involved in cancer research.

  • Provides a clinical perspective on the development of new molecularly targeted anticancer agents with the latest and most promising chemotherapeutic approaches
  • Offers a broad view of where the field is going, what tools drug discovery is using to produce new agents and how they are evaluated in the laboratory and clinic
  • Features 6 new chapters devoted to advances in technology and successful anticancer therapies, such as cancer genomics and personalized medicine, DNA-targeted agents, B-Raf inhibitors and more
  • Each chapter includes extensive references to the primary and review literature, as well as to relevant web-based sources


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17148

CAPA in the Pharmaceutical and Biotech Industries

How to Implement an Effective Nine Step Program

 

Woodhead Publishing, 2016.

ISBNs 9781907568589

Colección: ScienceDirect

Resumen (en inglés):

CAPA in the Pharmaceutical and Biotech Industries: How to Implement an Effective Nine Step Program contains the most current information on how to implement, develop, and maintain an effective Corrective Action and Preventive Action (CAPA) and investigation program using a nine step closed-loop process approach for medical devices and pharmaceutical and biologic manufacturers, as well as any anyone who has to maintain a quality system.This book addresses how companies often make the mistake of fixing problems in their processes by revising procedures or, more commonly, by retraining employees that may or may not have caused the problem. This event-focused fix leads to the false assumption that the errors have been eradicated and will be prevented in the future. The reality is that the causes of the failure were never actually determined, therefore the same problem will recur over and over. CAPA is a complete system that collects information regarding existing and potential quality problems. It analyzes and investigates the issues to identify the root cause of nonconformities. It is not just a quick-fix, simple approach, it is a process and has to be understood throughout organizations.

  • Provides an understanding of the principles and techniques involved in the effective implementation of a CAPA program, from the identification of the problem, to the verification of preventive action
  • Emphasis is placed on the practical aspects of how to perform failure investigations and root cause analysis through the use of several types of methodologies, all explained in detail
  • Provides effective methods to use with a Corrective Action system to help quality professionals identify costly issues and resolve them quickly and appropriately


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3192

Cardiac Drug Therapy

 

7a ed. Totowa, NJ: Humana Press Inc., 2007.

Título de la serie/colección: Contemporary Cardiology.

ISBNs 9781588299048 9781597452380

Colección: SpringerLink


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4659

Cardiac Safety of Noncardiac Drugs

Practical Guidelines for Clinical Research and Drug Development

 

13th ed. Totowa, NJ: Humana Press Inc., 2005.

ISBNs 9781588295156 9781592598847

Colección: SpringerLink


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17174

Case Studies in Nanotoxicology and Particle Toxicology

 

Academic Press, 2015.

ISBNs 9780128012154

Colección: ScienceDirect

Resumen (en inglés):

Case Studies in Nanotoxicology and Particle Toxicology presents a highly-illustrated analysis of the most prominent cases on the adverse effects of nanoparticles and their impact on humans and the environment.

This comprehensive reference demonstrates the possible risks imposed by managing and handling nanoparticles, showing the effects of involuntary inhalation or ingestion during their use and after their incineration.

Through the use of numerous examples, readers will discover the possible risks and effects of working with nanoparticles, along with best practices to prevent these effects. The text is an essential reference for anyone working in the risk assessment of nanoparticles, including nanosafety professionals, occupational toxicologists, regulatory toxicologists, and clinicians.

  • Presents real-life cases showing the potential risks to human health following exposure to nanoparticles
  • An ideal reference for anyone working in the risk assessment of nanoparticles, including nanosafety professionals, occupational toxicologists, regulatory toxicologists, and clinicians
  • Provides examples to help assess risks of handling engineered nanomaterials
  • Advises on the best forms of protection and the safest nanotechnological products


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5742

Cell Surface Receptors

A Short Course on Theory and Methods

 

3rd ed. Boston, MA: Springer Science+Business Media, 2005.

ISBNs 9780387230696 9780387230801

Colección: SpringerLink


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8395

Cell-Cycle Mechanisms and Neuronal Cell Death

 

13th ed. Boston, MA: Eurekah.com/Kluwer Academic/Plenum Publishers, 2005.

Título de la serie/colección: Neuroscience Intelligence Unit.

ISBNs 9780306478505 9780387293905

Colección: SpringerLink


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23392

Changing faces of glutathione, a cellular protagonist, The

 

Frontiers Media SA, 2015.

Título de la serie/colección: Frontiers Research Topics. ISSN 1664-8714,

ISBNs 9782889195954

Colección: Directory of Open Access Books


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17230

Chelation Therapy in the Treatment of Metal Intoxication

 

Academic Press, 2016.

ISBNs 9780128030721

Colección: ScienceDirect

Resumen (en inglés):

Chelation Therapy in the Treatment of Metal Intoxication presents a practical guide to the use of chelation therapy, from its basic chemistry, to available chelating antidotes, and the application of chelating agents. Several metals have long been known to be toxic to humans, and continue to pose great difficulty to treat. These challenges pose particular problems in industrial settings, with lead smelting known to be associated with hemopoietic alterations and paralyses, and the inhalation of mercury vapor in mercury mining being extremely detrimental to the central nervous system.

Clinical experience has demonstrated that acute and chronic human intoxications with a range of metals can be treated efficiently by administration of chelating agents. Chelation Therapy in the Treatment of Metal Intoxication describes the chemical and biological principles of chelation in the treatment of these toxic metal compounds, including new chelators such as meso-2,3-dimercaptosuccinic acid (DMSA) and D,L-2,3-dimercapto-1-propanesulfonic acid (DMPS).

  • Presents all the current findings on the potential for chelation as a therapy for metal intoxication
  • Presents practical guidelines for selecting the most appropriate chelating agent
  • Includes coverage on radionuclide exposure and metal storage diseases
  • Describes the chemical and biological principles of chelation in the treatment of toxic metal compounds


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