Criterios de búsqueda

Gran Área: Ciencias médicas y de la salud
Área: Medicina básica
Subárea: Farmacología y farmacia

Búsqueda

 


Resultado: 243 registro(s)

9621

Apoptosis, Senescence, and Cancer

 

13th ed. Totowa, NJ: Humana Press Inc., 2007.

Título de la serie/colección: Cancer Drug Discovery and Development.

ISBNs 9781588295279 9781597452212

Colección: SpringerLink


Cobertura temática

Acceder

9077

Apoptotic Pathways as Targets for Novel Therapies in Cancer and Other Diseases

 

13th ed. Boston, MA: Springer Science+Business Media, 2005.

ISBNs 9780387233840 9780387236957

Colección: SpringerLink


Cobertura temática

Acceder

9534

Application of Apoptosis to Cancer Treatment

 

13th ed. Dordrecht: Springer, 2005.

ISBNs 9781402033032 9781402033025

Colección: SpringerLink


Cobertura temática

Acceder

16788

Aquatic Ecotoxicology

Advancing Tools for Dealing with Emerging Risks

 

Academic Press, 2015.

ISBNs 9780128009499

Colección: ScienceDirect

Resumen (en inglés):

Aquatic Ecotoxicology: Advancing Tools for Dealing with Emerging Risks presents a thorough look at recent advances in aquatic ecotoxicology and their application in assessing the risk of well-known and emerging environmental contaminants.

This essential reference, brought together by leading experts in the field, guides users through existing and novel approaches to environmental risk assessment, then presenting recent advances in the field of ecotoxicology, including omics-based technologies, biomarkers, and reference species.

The book then demonstrates how these advances can be used to design and perform assays to discover the toxicological endpoints of emerging risks within the aquatic environment, such as nanomaterials, personal care products, PFOS and chemical mixtures. The text is an invaluable reference for any scientist who studies the effects of contaminants on organisms that live within aquatic environments.

  • Provides the latest perspectives on emerging toxic risks to aquatic environments, such as nanomaterials, pharmaceuticals, chemical mixtures, and perfluorooctane sulfonate (PFOS)
  • Offers practical guidance on recent advances to help in choosing the most appropriate toxicological assay
  • Presents case studies and information on a variety of reference species to help put the ecotoxicological theory into practical risk assess


Cobertura temática

Acceder

16804

Artificial Neural Network for Drug Design, Delivery and Disposition

 

Academic Press, 2016.

ISBNs 9780128015599

Colección: ScienceDirect

Resumen (en inglés):

Artificial Neural Network for Drug Design, Delivery and Disposition provides an in-depth look at the use of artificial neural networks (ANN) in pharmaceutical research. With its ability to learn and self-correct in a highly complex environment, this predictive tool has tremendous potential to help researchers more effectively design, develop, and deliver successful drugs.

This book illustrates how to use ANN methodologies and models with the intent to treat diseases like breast cancer, cardiac disease, and more. It contains the latest cutting-edge research, an analysis of the benefits of ANN, and relevant industry examples. As such, this book is an essential resource for academic and industry researchers across the pharmaceutical and biomedical sciences.

  • Written by leading academic and industry scientists who have contributed significantly to the field and are at the forefront of artificial neural network (ANN) research
  • Focuses on ANN in drug design, discovery and delivery, as well as adopted methodologies and their applications to the treatment of various diseases and disorders
  • Chapters cover important topics across the pharmaceutical process, such as ANN in structure-based drug design and the application of ANN in modern drug discovery
  • Presents the future potential of ANN-based strategies in biomedical image analysis and much more


Cobertura temática

Acceder

16836

Atlas of Histology of the Juvenile Rat

 

Academic Press, 2016.

ISBNs 9780128026823

Colección: ScienceDirect

Resumen (en inglés):

Atlas of Histology of the Juvenile Rat should be of interest to toxicologic pathologists, toxicologists, and other biological scientists who are interested in the histomorphology of juvenile rats. For several decades the laboratory rat has been used extensively in nonclinical toxicology studies designed to detect potential human toxicity of drugs, agrochemicals, industrial chemicals, and environmental hazards. These studies traditionally have involved young adult rats that are 8-10 weeks of age as studies are started. It is becoming increasingly apparent that children and young animals may have different responses to drug/chemical exposures, therefore, regulatory agencies are emphasizing toxicology studies in juvenile animals.

While the histologic features of organs from young adult and aged laboratory rats are well known, less is known about the histologic features of organs from juvenile rats. Final histologic maturity of many organs is achieved postnatally, thus immature histologic features must be distinguished from chemical- or drug-related effects. While this postnatal organ development is known to exist as a general concept, detailed information regarding postnatal histologic development is not readily available. The Atlas includes organs that are typically sampled in nonclinical toxicology studies and presents the histologic features at weekly intervals, starting at birth and extending through postnatal day 42.

  • Written and edited by highly experienced, board-certified toxicologic pathologists
  • Includes more than 700 high-resolution microscopic images from organs that are typically examined in safety assessment toxicology studies
  • Detailed figure legends and chapter narratives present the salient features of each organ at each time interval
  • Figures are available for further study via Elsevier’s Virtual Microscope, which allows viewing of microscopic images at higher magnification
  • Valuable resource for toxicologic pathologists who are confronted with interpretation of lesions in juvenile rats in situations where age-matched concurrent controls are not available for comparison, e.g., with unscheduled decedents
  • Figures are available for further study on ScienceDirect with Virtual Microscope, which allows viewing of microscopic images at higher magnification


Cobertura temática

Acceder

16847

Au, U, Fe, Mn, Hg, Sb, W, and P Deposits

Vol. 7

 

Elsevier, 1976.

ISBNs 9780444414076

Colección: ScienceDirect

Resumen (en inglés): Handbook of Strata-Bound and Stratiform Ore Deposits, Volume 7: Au, U, Fe, Mn, Hg, Sb, W, and P Deposits focuses on the characteristics, properties, origins, and structures of Au, U, Fe, Mn, Hg, Sb, W, and P deposits.

The selection first elaborates on gold in the Proterozoic sediments of South Africa, nature of the Witwatersrand gold-uranium deposits, and origin of Western-States type uranium mineralization. Discussions focus on tectonic conditions, sedimentation, mineralization and alteration, architecture of the Witwatersrand Basin, source of wealth in the Witwatersrand Basin, gold mineralization in South Africa, and ground-rules for gold prospecting. The text then ponders on origin of the Precambrian banded iron-formations, aspects of the sedimentary petrology of cherty iron-formation, and genetic problems and environmental features of volcanosedimentary iron-ore deposits of the Lahn-Dill Type. Concerns cover geological setting, crystallization structures, origin of cherty iron-formations, similarities and differences between banded and oolitic iron-formations, regional geologic distribution, and general diagnostic statement. The manuscript examines sedimentary phosphate deposits, ancient manganese deposits, and freshwater ferromanganese deposits.

The selection is a dependable reference for researchers wanting to explore Au, U, Fe, Mn, Hg, Sb, W, and P deposits.


Cobertura temática

Acceder

22590

Autonomes Fahren

Technische, rechtliche und gesellschaftliche Aspekte

 

Springer, 2015.

ISBNs 9783662458532 9783662458549

Colección: Directory of Open Access Books


Cobertura temática

Acceder

23233

Beyond the Limits to Growth

 

Springer, 2014.

Título de la serie/colección: Science for Sustainable Societies. ISSN 2197-7356,

ISBNs 9784431545583 9784431545590

Colección: Directory of Open Access Books


Cobertura temática

Acceder

16910

Biased Signaling in Physiology, Pharmacology and Therapeutics

 

Academic Press, 2014.

ISBNs 9780124114609

Colección: ScienceDirect

Resumen (en inglés):

Biased Signaling in Physiology, Pharmacology and Therapeutics is a unique and essential reference for the scientific community concerning how conformational-dependent activation is a common phenomenon across many classes of receptors or signaling molecules. It discusses the role of conformational dynamics in leading to signaling bias across different classes of receptors and signaling molecules. By providing a broader view of signaling bias, this resource helps to explain common mechanisms shared across receptor classes and how this can be utilized to elucidate their cellular activity and better understand their therapeutic potential.

Written for both new and established scientists in pharmacology, cell biology, biochemistry, and signal transduction, as well as physicians, this book clearly illustrates how biased receptor signaling can be utilized to develop and understand complex pharmacology. Chapters are each focused on a specific class of receptor or other important topic and make use of real-world examples illustrating how the latest research in signal transduction has led to a better understanding of pharmacology and cell biology. This structure creates a basis for understanding that physiological signalling bias has been selected by nature in order to provide complex and tissue- specific biological responses in the face of limited receptors and signaling pathways. This book provides a framework to reveal that these physiological mechanisms are not restricted to one receptor type or family and thus presents receptor signaling from a newer, more global perspective.

  • Offers a unique and valuable resource on biased receptor signaling that provides a global view for better understanding pharmacology across many receptor families
  • Integrates biased receptor signaling, physiology, and pharmacology to place this emerging science within the context of treating disease
  • Includes important chapters on both the pharmaceutical and therapeutic implications of biased signaling


Cobertura temática

Acceder


Los iconos de las disciplinas fueron generados desde flaticon.com bajo licencia CC BY.